The College of Life Sciences, Zhejiang University, Hangzhou, 310036, China.
Institute of Life Sciences, College of Life and Environmental Sciences, Hangzhou Normal University, Hangzhou, 310036, China.
Sci Rep. 2017 Mar 23;7(1):337. doi: 10.1038/s41598-017-00407-1.
Myelin elaborated by oligodendrocytes (OLs) in the central nervous system (CNS) is required for saltatory conduction of action potentials along neuronal axons. We found that TMEFF2, a transmembrane protein with EGF-like and two follistatin-like domains, is selectively expressed in differentiating/myelinating OLs. Previous studies showed that TMEFF2 is capable of binding to PDGFA, which plays important roles in the proliferation, migration and differentiation of oligodendrocyte progenitor cells (OPCs). However, molecular and genetic analysis revealed that Tmeff2 is a weak binder of PDGFA, and not required for OL differentiation and myelin gene expression in vivo. Together, our data suggested that Tmeff2 is specifically upregulated in OLs, but dispensable for OL differentiation and maturation.
少突胶质细胞（OLs）在中枢神经系统（CNS）中产生的髓鞘对于动作电位沿神经元轴突的跳跃传导是必需的。我们发现，跨膜蛋白 TMEFF2 具有表皮生长因子样和两个卵泡抑素样结构域，选择性地在分化/髓鞘形成 OLs 中表达。先前的研究表明，TMEFF2 能够与 PDGFA 结合，PDGFA 在少突胶质前体细胞（OPC）的增殖、迁移和分化中发挥重要作用。然而，分子和遗传分析表明，Tmeff2 与 PDGFA 的结合能力较弱，并且在体内对 OL 分化和髓鞘基因表达不是必需的。综上所述，我们的数据表明，Tmeff2 在 OLs 中特异性地上调，但对 OL 分化和成熟不是必需的。
