Synthesis and antimalarial potential of some novel quinoline-pyrazolopyridine derivatives.

A series of 1-(4-methylquinolin-2-yl)-4,6-diaryl-1H-pyrazolo[3,4-b]pyridin-3-amine derivatives was synthesized by the reaction of 3-cinnamoyl-4-hydroxy-6-methyl-2-pyran-2-ones with 2-chloro-4,6-diphenylnicotinonitrile analogues in the presence of 2-hydrazino-4-methyl quinoline and ethanol. The newly synthesized compounds were characterized by IR, H NMR and mass spectral data. The synthetic series of novel quinoline-pyrazolopyridine hybrids were screened for schizont maturation assay against chloroquine sensitive 3D7 strain of , from which the most five active analogues were further evaluated for 4-day suppressive test in Swiss albino mice. Among the series, (containing 4-Cl substituent attached to both aryl ring) portrayed considerable potent antimalarial activity during as well as study.