Anvari Sohrab, Bahaoddini Aminollah, Moein Mahmoodreza, Khosravi Ahmad Reza
Department of Biology, College of Sciences, Shiraz University, Shiraz, Iran.
Department of Pharmacognosy, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran.
EXCLI J. 2016 Dec 7;15:797-806. doi: 10.17179/excli2016-529. eCollection 2016.
(Asteraceae) is a medicinal plant commonly used in Iran. This study was performed to determine the cardiovascular effects of hydroethanolic extract of . (HEAE) and the underlying mechanisms in anaesthetized rats. The acute effects of intravenous (i.v.) administration of different doses of HEAE (40, 50, 60, 80 mg/kg), and its probable interaction with cholinergic and nitrergic systems were investigated in the presence of ACh and NOS blocker (L-NAME) as well as ethanol (HEAE solvent in sham group). Intravenous administration of different doses of HEAE induced hypotension. HEAE (60 mg/kg) significantly reduced mean arterial blood pressure (MAP), systolic arterial blood pressure (SBP) and diastolic arterial blood pressure (DBP) compared to control rats that treated with ethanol only, but no change in heart rate (HR) was seen in both groups. The results showed significant decrease in MAP, SBP, DBP and increase of HR in the presence of HEAE plus ACh (10 µg/kg) compared to when ACh was injected alone. Finally i.v. administration of HEAE, significantly reduced MAP and DBP in L-NAME (5 mg/kg) treated animals, while bradycardic responses to L-NAME were not significantly changed by HEAE. It can be concluded that induced hypotensive effect via lowering total peripheral resistance and cardiac output that may be synergist with cholinergic and independent of nitrergic system.
菊科植物是伊朗常用的药用植物。本研究旨在确定[菊科植物名称]水乙醇提取物（HEAE）对麻醉大鼠的心血管作用及其潜在机制。研究了静脉注射不同剂量的HEAE（40、50、60、80mg/kg）的急性效应，以及在乙酰胆碱（ACh）和一氧化氮合酶阻滞剂（L-NAME）存在的情况下其与胆碱能和一氧化氮能系统的可能相互作用，同时还研究了乙醇（假手术组中HEAE的溶剂）的作用。静脉注射不同剂量的HEAE可引起低血压。与仅用乙醇处理的对照大鼠相比，HEAE（60mg/kg）显著降低了平均动脉血压（MAP）、收缩动脉血压（SBP）和舒张动脉血压（DBP），但两组心率（HR）均无变化。结果显示，与单独注射ACh相比，在HEAE加ACh（10μg/kg）存在的情况下，MAP、SBP、DBP显著降低，HR升高。最后，静脉注射HEAE可显著降低L-NAME（5mg/kg）处理动物的MAP和DBP，而HEAE对L-NAME引起的心动过缓反应无显著影响。可以得出结论，[菊科植物名称]通过降低总外周阻力和心输出量诱导降压作用，这可能与胆碱能系统协同作用且独立于一氧化氮能系统。
