Jiang Ziyu, Jacob Joe A, Loganathachetti Dinesh S, Nainangu Prasannabalaji, Chen Baoan
Department of Hematology and Oncology, Zhongda Hospital, School of Medicine, Southeast UniversityNanjing, China; Department of Oncology, Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese MedicineNanjing, China.
Department of Hematology and Oncology, Zhongda Hospital, School of Medicine, Southeast University Nanjing, China.
Front Pharmacol. 2017 Mar 9;8:105. doi: 10.3389/fphar.2017.00105. eCollection 2017.
Over the past decade, screening and identifying novel compounds for their biomedical applications has become an upcoming area of research. Identifying the molecular mechanisms of these compounds has become an integral part of anticancer research. β-elemene, a sesquiterpene, is renowned for its anticancer activity against a variety of cell lines. Recent studies on β-elemene have elucidated that it possesses anti-proliferative effect on cancer cells by creating an apoptotic trigger. Interestingly, it also induces protective autophagy in some cancerous cell lines and is less cytotoxic compared to other widely accepted chemotherapeutic agents. This provides an edge with the perception of limited toxicity to normal cells. This mini-review precisely focuses on the studies performed to identify the mechanism of anticancer activity of β-elemene against cancer cells of multiple origin. In accordance to the evaluation made by the studies mentioned, apoptosis has been identified to be most possible reason behind anticancer activity exerted by β-elemene against a variety of cancer cell lines. Cell cycle arrest and necrosis have been credited to be possible alternate mechanisms for the anticancer effect of β-elemene.
在过去十年中，筛选和鉴定具有生物医学应用价值的新型化合物已成为一个新兴的研究领域。确定这些化合物的分子机制已成为抗癌研究不可或缺的一部分。β-榄香烯，一种倍半萜烯，以其对多种细胞系的抗癌活性而闻名。最近对β-榄香烯的研究表明，它通过引发凋亡触发对癌细胞具有抗增殖作用。有趣的是，它还能在一些癌细胞系中诱导保护性自噬，并且与其他广泛认可的化疗药物相比细胞毒性较小。这在对正常细胞毒性有限的认知方面具有优势。本综述精确聚焦于为确定β-榄香烯对多种来源癌细胞的抗癌活性机制而进行的研究。根据上述研究所作的评估，已确定凋亡是β-榄香烯对多种癌细胞系发挥抗癌活性背后最可能的原因。细胞周期阻滞和坏死被认为是β-榄香烯抗癌作用可能的替代机制。
