Murtaza Babar, Hichami Aziz, Khan Amira S, Ghiringhelli François, Khan Naim A
Physiologie de la Nutrition and Toxicologie, UMR U866 Institut National de la Santé et de la Recherche Médicale/Université de Bourgogne-Franche Compté/Agro-Sup Dijon, France.
UMR U866 Institut National de la Santé et de la Recherche Médicale/Université de Bourgogne-Franche Compté, Chimiothérapie et Réponse Anti-tumorale Dijon, France.
Front Physiol. 2017 Mar 8;8:134. doi: 10.3389/fphys.2017.00134. eCollection 2017.
The sense of taste is responsible for the detection and ingestion of food to cover energetic requirements in health and disease. The change in taste perception might lead to malnutrition that is usually one of the frequent causes of morbidity and mortality in patients with cancer. In this review, we summarize the mechanisms of taste perception and how they are altered in cancer. We also address the question of the implication of inflammation, responsible for the alterations in taste modalities. We highlight the role of radio- and chemotherapy in the modulation of taste physiology. Other several factors like damage to taste progenitor cells and disruption of gut microbiota are also dealt with relation to taste perception in cancer. We further shed light on how to restore taste acuity, by using different preventive methods, dietary modifications and pharmacotherapy in subjects with advanced cancer state.
味觉负责检测和摄取食物，以满足健康和疾病状态下的能量需求。味觉感知的变化可能导致营养不良，而营养不良通常是癌症患者发病和死亡的常见原因之一。在本综述中，我们总结了味觉感知的机制以及它们在癌症中是如何改变的。我们还探讨了炎症在味觉改变中的作用问题。我们强调了放疗和化疗在调节味觉生理方面的作用。其他几个因素，如味觉祖细胞的损伤和肠道微生物群的破坏，也与癌症中的味觉感知有关。我们进一步阐明了如何通过使用不同的预防方法、饮食调整和药物治疗，在晚期癌症患者中恢复味觉敏锐度。
