暴露于HIV的未感染婴儿中性粒细胞氧化爆发受损病例——一项试点研究。
Cases of Impaired Oxidative Burst in HIV-Exposed Uninfected Infants' Neutrophils-A Pilot Study.
作者信息
Maloupazoa Siawaya Anicet Christel, Mveang-Nzoghe Amandine, Mvoundza Ndjindji Ofilia, Mintsa Ndong Armel, Essone Paulin N, Djoba Siawaya Joel Fleury
机构信息
Unités de Recherche et de Diagnostics Spécialisés, Laboratoire National de Santé Publique , Libreville , Gabon.
Unité de Virologie, Laboratoire National de Santé Publique , Libreville , Gabon.
出版信息
Front Immunol. 2017 Mar 9;8:262. doi: 10.3389/fimmu.2017.00262. eCollection 2017.
An increased risk of serious bacterial infections in HIV-exposed uninfected (HEU) infants has been demonstrated. Although neutrophils are essential for the protection of infants against bacterial infections, no study has investigated their profile in HEU infants to date. In this study, we assessed the function of neutrophils in HEU infants using the nitroblue tetrazolium reduction test. Among 25 HEU infants, 9 (36%) showed a reduced ability of their neutrophils to produce reactive oxygen species upon stimulation with bacteria. No alteration of total neutrophil counts was noted in the blood of HEU infants indicating that the alteration observed in the 36% of HEU infants may only be functional. Conclusively, impaired neutrophil function could be a factor of vulnerability in HEU infants.
已证实，暴露于HIV但未受感染（HEU）的婴儿发生严重细菌感染的风险增加。尽管中性粒细胞对于保护婴儿免受细菌感染至关重要，但迄今为止尚无研究调查过HEU婴儿中性粒细胞的情况。在本研究中，我们使用硝基蓝四氮唑还原试验评估了HEU婴儿中性粒细胞的功能。在25名HEU婴儿中，9名（36%）的中性粒细胞在受到细菌刺激后产生活性氧的能力降低。HEU婴儿血液中的中性粒细胞总数没有变化，这表明在36%的HEU婴儿中观察到的变化可能只是功能性的。总之，中性粒细胞功能受损可能是HEU婴儿易患感染的一个因素。
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