母婴 HIV 暴露、喂养状况和微生物组对婴儿细胞免疫的影响。
Impact of maternal HIV exposure, feeding status, and microbiome on infant cellular immunity.
机构信息
Division of Immunology, Institute of Infectious Diseases and Molecular Medicine, University of Cape Town, Cape Town, South Africa.
Seattle Children's Research Institute and Departments of Paediatrics and Global Health, University of Washington, Seattle, Washington, USA.
出版信息
J Leukoc Biol. 2019 Feb;105(2):281-289. doi: 10.1002/JLB.MR0318-120R. Epub 2018 Dec 21.
At least one-third of infants born in sub-Saharan Africa have been exposed to the effects of maternal HIV infection and antiretroviral treatment. Intrauterine HIV exposure is associated with increased rates of morbidity and mortality in children. Although the mechanisms responsible for poor infant health with HIV-1 exposure are likely to be multifactorial, we posit that the maternal environment during gestation and in the perinatal period results in altered infant immunity and is possibly the strongest contributing factor responsible for the disproportionally high infectious events among HIV-exposed infants who remain HIV uninfected. This review provides a synthesis of studies reporting the impact of intrauterine HIV exposure, feeding practices, and microbiota on immune ontogeny in the first year of life in HIV-exposed uninfected infants.
在撒哈拉以南非洲出生的婴儿中，至少有三分之一受到了母婴 HIV 感染和抗逆转录病毒治疗的影响。子宫内 HIV 暴露与儿童发病率和死亡率的增加有关。虽然导致 HIV-1 暴露的婴儿健康状况不佳的机制可能是多因素的，但我们假设妊娠和围产期期间的母体环境导致婴儿免疫改变，并且可能是导致 HIV 暴露但未感染的婴儿中不成比例的高感染事件的最强促成因素。本综述综合了报告宫内 HIV 暴露、喂养方式和微生物组对 HIV 未感染暴露婴儿生命第一年免疫发生的影响的研究。
Zotero 插件