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印度首次报告从血流感染中分离出携带 IncX3 质粒的:快速传播的可能性。

First Indian report of IncX3 plasmid carrying in from bloodstream infection: potential for rapid dissemination.

作者信息

Devanga Ragupathi N K, Muthuirulandi Sethuvel D P, Gajendiran R, Daniel J L K, Walia K, Veeraraghavan B

机构信息

Department of Clinical Microbiology, Christian Medical College, Vellore, India.

Division of Epidemiology and Communicable Diseases, Indian Council of Medical Research, New Delhi, India.

出版信息

New Microbes New Infect. 2017 Feb 2;17:65-68. doi: 10.1016/j.nmni.2017.01.012. eCollection 2017 May.

Abstract

with is only infrequently observed. Self-transmissible plasmids carrying the gene increase the dissemination of carbapenem resistance in developing countries. This study investigates the whole genome sequence of a -positive . The isolate was an extended-spectrum β-lactamase producer by combined disc diffusion test and carbapenemase producer by CarbaNP method. Sequencing results revealed the isolate as ST-167 with IncX3 plasmid carrying in addition to and genes. The identification of IncX3- combination is the first report in India where is known to cause higher resistance to carbapenems compared to its variants.

摘要

这种情况仅偶尔被观察到。携带该基因的自我传递质粒增加了发展中国家碳青霉烯耐药性的传播。本研究调查了一株该阳性菌株的全基因组序列。通过联合纸片扩散试验,该分离株为超广谱β-内酰胺酶产生菌,通过CarbaNP方法检测为碳青霉烯酶产生菌。测序结果显示该分离株为ST-167,带有IncX3质粒,除了其他基因外还携带该基因。IncX3与该基因组合的鉴定在印度尚属首次报道,已知该基因与其变体相比,对碳青霉烯类药物具有更高的耐药性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f699/5350569/68ec489d501d/gr1.jpg

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