微小RNA-429介导结直肠癌的肿瘤生长和转移。
miR-429 mediates tumor growth and metastasis in colorectal cancer.
作者信息
Han Yantao, Zhao Qian, Zhou Jie, Shi Rui
机构信息
Qingdao University Qingdao 266071, Shandong, China.
Qingdao University Affiliated Hospital Qingdao 266071, Shandong, China.
出版信息
Am J Cancer Res. 2017 Feb 1;7(2):218-233. eCollection 2017.
Abstract
Colorectal cancer (CRC), presenting the third most common malignancy worldwide. In recent years, the aberrantly upregulation or downregulation of miRNAs in CRC have been evidenced in a number of studies. In this study, our results showed that the expression of miR-429 was significantly higher in CRC tissue compared with adjacent non-tumor tissue. In addition, our findings showed that miR-429 level was significantly associated with clinicoplathological features and prognosis of patients with CRC. Moreover, our findings showed that miR-429 exerted oncogenic effect by directly targeting HOXA5, a transcription factor of HOX families that is involved in the development and progression of CRC.
摘要
结直肠癌（CRC）是全球第三大常见恶性肿瘤。近年来，多项研究证实了CRC中miRNAs的异常上调或下调。在本研究中，我们的结果显示，与相邻非肿瘤组织相比，miR-429在CRC组织中的表达显著更高。此外，我们的研究结果表明，miR-429水平与CRC患者的临床病理特征和预后显著相关。而且，我们的研究结果表明，miR-429通过直接靶向HOXA5发挥致癌作用，HOXA5是HOX家族的一个转录因子，参与CRC的发生和发展。
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