Han Yantao, Zhao Qian, Zhou Jie, Shi Rui
Qingdao University Qingdao 266071, Shandong, China.
Qingdao University Affiliated Hospital Qingdao 266071, Shandong, China.
Am J Cancer Res. 2017 Feb 1;7(2):218-233. eCollection 2017.
Colorectal cancer (CRC), presenting the third most common malignancy worldwide. In recent years, the aberrantly upregulation or downregulation of miRNAs in CRC have been evidenced in a number of studies. In this study, our results showed that the expression of miR-429 was significantly higher in CRC tissue compared with adjacent non-tumor tissue. In addition, our findings showed that miR-429 level was significantly associated with clinicoplathological features and prognosis of patients with CRC. Moreover, our findings showed that miR-429 exerted oncogenic effect by directly targeting HOXA5, a transcription factor of HOX families that is involved in the development and progression of CRC.
结直肠癌（CRC）是全球第三大常见恶性肿瘤。近年来，多项研究证实了CRC中miRNAs的异常上调或下调。在本研究中，我们的结果显示，与相邻非肿瘤组织相比，miR-429在CRC组织中的表达显著更高。此外，我们的研究结果表明，miR-429水平与CRC患者的临床病理特征和预后显著相关。而且，我们的研究结果表明，miR-429通过直接靶向HOXA5发挥致癌作用，HOXA5是HOX家族的一个转录因子，参与CRC的发生和发展。
