黑色素瘤相关抗原A（MAGE-A）与癌症免疫治疗
MAGE-A Antigens and Cancer Immunotherapy.
作者信息
Zajac Paul, Schultz-Thater Elke, Tornillo Luigi, Sadowski Charlotte, Trella Emanuele, Mengus Chantal, Iezzi Giandomenica, Spagnoli Giulio C
机构信息
Oncology Surgery, Department of Biomedicine, University Hospital of Basel , Basel , Switzerland.
Department of Pathology, University Hospital of Basel , Basel , Switzerland.
出版信息
Front Med (Lausanne). 2017 Mar 8;4:18. doi: 10.3389/fmed.2017.00018. eCollection 2017.
MAGE-A antigens are expressed in a variety of cancers of diverse histological origin and germinal cells. Due to their relatively high tumor specificity, they represent attractive targets for active specific and adoptive cancer immunotherapies. Here, we (i) review past and ongoing clinical studies targeting these antigens, (ii) analyze advantages and disadvantages of different therapeutic approaches, and (iii) discuss possible improvements in MAGE-A-specific immunotherapies.
MAGE-A抗原在多种组织学来源不同的癌症以及生殖细胞中表达。由于它们具有相对较高的肿瘤特异性，因此是主动特异性和过继性癌症免疫疗法颇具吸引力的靶点。在此，我们（i）回顾过去及正在进行的针对这些抗原的临床研究，（ii）分析不同治疗方法的优缺点，以及（iii）讨论MAGE-A特异性免疫疗法可能的改进之处。
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