Yuda Emi, Ando Tomoki, Ishida Yukihiro, Sakano Hiroyuki, Yoshida Yutaka
Innovation Center for Semiconductor and Digital Future, Mie University, Tsu 514-0000, Japan.
Department of Management Science and Technology, Graduate School of Engineering, Tohoku University, Sendai 982-0002, Japan.
Adv Respir Med. 2025 Jul 21;93(4):26. doi: 10.3390/arm93040026.
Measurement of nitric oxide (NO) concentration in exhaled breath (FeNO) is a quantitative, non-invasive, simple, and safe method for assessing airway inflammation. It serves as a complementary tool to other methods for evaluating airway diseases. However, little is known about the typical NO levels in healthy individuals, including individual differences and the influence of measurement timing. Therefore, this study classified measurement times into four periods and statistically analyzed NO levels in healthy individuals. The mean values among groups were compared using repeated measures ANOVA on six participants. The analysis showed large individual variations in NO levels, resulting in no significant difference ( = 0.29). Notably, greater fluctuations were observed in the morning. These findings align with previous studies suggesting the influence of circadian rhythms and the redundancy of repeated measurements. This study highlights the need to consider timing and individual variability when using FeNO as a physiological marker in healthy populations.
测量呼出气中一氧化氮（NO）浓度（FeNO）是一种用于评估气道炎症的定量、非侵入性、简单且安全的方法。它是评估气道疾病的其他方法的补充工具。然而，对于健康个体的典型NO水平，包括个体差异和测量时间的影响，人们了解甚少。因此，本研究将测量时间分为四个时段，并对健康个体的NO水平进行了统计分析。对六名参与者使用重复测量方差分析比较了各组的平均值。分析显示NO水平存在较大的个体差异，结果无显著差异（ = 0.29）。值得注意的是，早晨观察到的波动更大。这些发现与先前关于昼夜节律影响和重复测量冗余性的研究一致。本研究强调在健康人群中将FeNO用作生理标志物时需要考虑测量时间和个体变异性。
