绵羊腐蹄病中与细菌失调相关的独特皮肤炎症。
A distinct bacterial dysbiosis associated skin inflammation in ovine footrot.
机构信息
University of Nottingham, School of Veterinary Medicine and Science, Sutton Bonington, United Kingdom.
Department of Biomedical Sciences and Veterinary Public Health, Swedish University of Agricultural Sciences, Uppsala, Sweden.
出版信息
Sci Rep. 2017 Mar 24;7:45220. doi: 10.1038/srep45220.
Ovine footrot is a highly prevalent bacterial disease caused by Dichelobacter nodosus and characterised by the separation of the hoof horn from the underlying skin. The role of innate immune molecules and other bacterial communities in the development of footrot lesions remains unclear. This study shows a significant association between the high expression of IL1β and high D. nodosus load in footrot samples. Investigation of the microbial population identified distinct bacterial populations in the different disease stages and also depending on the level of inflammation. Treponema (34%), Mycoplasma (29%) and Porphyromonas (15%) were the most abundant genera associated with high levels of inflammation in footrot. In contrast, Acinetobacter (25%), Corynebacteria (17%) and Flavobacterium (17%) were the most abundant genera associated with high levels of inflammation in healthy feet. This demonstrates for the first time there is a distinct microbial community associated with footrot and high cytokine expression.
绵羊腐蹄病是一种由溶组织梭菌引起的高度流行的细菌性疾病，其特征是蹄角质与下面的皮肤分离。先天免疫分子和其他细菌群落在腐蹄病病变发展中的作用仍不清楚。本研究表明，在腐蹄病样本中，IL1β 的高表达与高 D. nodosus 负荷之间存在显著关联。对微生物种群的调查发现，不同疾病阶段和炎症程度存在不同的细菌种群。与腐蹄病的高炎症水平相关的最丰富的属为密螺旋体（34%）、支原体（29%）和卟啉单胞菌（15%）。相比之下，与健康足部高炎症水平相关的最丰富的属为不动杆菌（25%）、棒状杆菌（17%）和黄杆菌（17%）。这是首次证明存在与腐蹄病和高细胞因子表达相关的独特微生物群落。
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