钯催化的通过瞬态导向基团实现的芳基酮的直接邻位 C-H 芳基化。
Pd-Catalyzed Direct ortho-C-H Arylation of Aromatic Ketones Enabled by a Transient Directing Group.
机构信息
State Key Laboratory and Institute of Elemento-organic Chemistry, School of Chemistry, Nankai University , Tianjin 300071, China.
出版信息
Org Lett. 2017 Apr 7;19(7):1562-1565. doi: 10.1021/acs.orglett.7b00363. Epub 2017 Mar 24.
PMID:28338326
Abstract
The Pd-catalyzed direct C(sp)-H arylation of aromatic ketones using a transient directing group is described. The ketimine/carboxylate bidentate directing group in situ generated from aromatic ketone and glycine enabled a palladium-catalyzed ortho-C-H arylation, which shows extensive substrate compatibility.
摘要
本文描述了使用瞬态导向基团钯催化的芳基酮的直接 C(sp)-H 芳基化反应。由芳基酮和甘氨酸原位生成的亚胺/羧酸双齿导向基团使钯催化的邻位 C-H 芳基化反应成为可能，具有广泛的底物适用性。
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