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结合过渡金属与瞬态导向基团用于C-H官能团化反应。

Combining transition metals and transient directing groups for C-H functionalizations.

作者信息

Bhattacharya Trisha, Pimparkar Sandeep, Maiti Debabrata

机构信息

Department of Chemistry, IIT Bombay Powai Mumbai-400076 India

IITB-Monash Research Academy, IIT Bombay Powai Mumbai-400076 India.

出版信息

RSC Adv. 2018 May 29;8(35):19456-19464. doi: 10.1039/c8ra03230k. eCollection 2018 May 25.

DOI:10.1039/c8ra03230k
PMID:35541005
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9080754/
Abstract

In the domain of synthetic chemistry, C-H bond activation has always remained in the spotlight for researchers over the last few decades. Although different strategies have been employed to chemically trigger unactivated C-H bonds, transition metal catalyzed directing group (DG) aided C-H bond activation is the most explored pathway of all because of its ability to perform diverse site selective functional metamorphosis. Despite its popularity, tedious synthetic methodology requiring additional steps for the installation and removal of DGs from the target substrate diminishes its efficacy. However, replacement of directing groups by transient directing groups (tDGs) reduces the hurdle to a greater extent without compromising the product yield and selectivity. In this report we have depicted the intense journey of transient directing groups with three (Rh, Ru, and Pd) prevalent second row transition metals.

摘要

在合成化学领域，在过去几十年里，C-H键活化一直是研究人员关注的焦点。尽管已经采用了不同的策略来化学触发未活化的C-H键，但过渡金属催化的导向基团（DG）辅助的C-H键活化是所有方法中研究最多的途径，因为它能够实现多种位点选择性官能团转变。尽管它很受欢迎，但繁琐的合成方法需要额外的步骤来在目标底物上安装和去除导向基团，这降低了它的效率。然而，用瞬态导向基团（tDG）取代导向基团在很大程度上减少了障碍，同时不影响产物收率和选择性。在本报告中，我们描述了瞬态导向基团与三种（铑、钌和钯）常见的第二周期过渡金属的紧密结合历程。

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