Department of Biochemical and Pharmaceutical Technology, School of Pharmaceutical Sciences, University of São Paulo, Brazil.
Department of Biochemistry and Tissue Biology, Institute of Biology, University of Campinas, Brazil.
Biomater Sci. 2016 Feb;4(2):205-18. doi: 10.1039/c5bm00360a.
Use of nanoscale devices as carriers for drugs and imaging agents has been extensively investigated and successful examples can already be found in therapy. In parallel, recombinant DNA technology together with molecular biology has opened up numerous possibilities for the large-scale production of many proteins of pharmaceutical interest, reflecting in the exponentially growing number of drugs of biotechnological origin. When we consider protein drugs, however, there are specific criteria to take into account to select adequate nanostructured systems as drug carriers. In this review, we highlight the main features, advantages, drawbacks and recent developments of nanostructures for protein encapsulation, such as nanoemulsions, liposomes, polymersomes, single-protein nanocapsules and hydrogel nanoparticles. We also discuss the importance of nanoparticle stabilization, as well as future opportunities and challenges in nanostructures for protein drug delivery.
将纳米级器件用作药物和成像剂的载体已经得到了广泛的研究，并且在治疗中已经有了成功的例子。与此同时，重组 DNA 技术与分子生物学一起为大规模生产许多具有药物应用价值的蛋白质提供了无数的可能性，这反映在生物技术来源的药物数量呈指数级增长。然而，当我们考虑蛋白质药物时，需要考虑特定的标准来选择合适的纳米结构系统作为药物载体。在这篇综述中，我们强调了用于蛋白质包封的纳米结构的主要特征、优点、缺点和最新进展，如纳米乳液、脂质体、聚合物囊泡、单蛋白纳米胶囊和水凝胶纳米颗粒。我们还讨论了纳米颗粒稳定化的重要性，以及在蛋白质药物传递的纳米结构中未来的机会和挑战。
