Becker T M, Magder L, Harrison H R, Stewart J A, Humphrey D D, Hauler J, Nahmias A J
Division of Sexually Transmitted Diseases, Center for Prevention Services, Centers for Disease Control, Atlanta, GA.
Am J Epidemiol. 1988 May;127(5):1071-8. doi: 10.1093/oxfordjournals.aje.a114883.
Investigations of serum antibody status to the five human herpesviruses--herpes simplex virus type 1, herpes simplex virus type 2, cytomegalovirus, Epstein-Barr virus, and varicella-zoster virus--were conducted on 197 Navajo children, aged 1-15 years, at a reservation pediatric outpatient clinic in Crownpoint, New Mexico, from 1981-1984. To determine the severity of infection with the human herpesviruses, the authors reviewed lifetime medical records of 166 of the children for evidence of herpesvirus-related diseases, and to illuminate potential modes of transmission of the viruses, they completed home interviews on the families of 87 of the children. The investigation showed that the children had a high prevalence of antibody to herpes simplex virus type 1 (73% of total sample), cytomegalovirus (78%), Epstein Barr virus (98%), and varicella-zoster virus (77%), and that prevalence tended to increase with age. None of the children demonstrated herpes simplex virus type 2 antibodies. The medical records showed that 30% of the children had suffered from gingivostomatitis prior to the study. When age was controlled for, the study showed herpes simplex virus type 1 seropositivity to be associated with children who slept in the same bed as their parents during infancy (p = 0.003) and with frequent attendance at community events (p = 0.02); cytomegalovirus seropositivity was shown to be associated with female sex (p = 0.007) and with living in a traditional Navajo dwelling (p = 0.007). The Navajo children also demonstrated a greater frequency of symptomatic oral herpes simplex virus type 1 infection than is usually recorded. The findings suggest a relation between certain patterns of cultural behavior and transmission of herpesvirus infections.
1981年至1984年期间，在新墨西哥州克朗波因特的一家保留地儿科门诊诊所，对197名年龄在1至15岁的纳瓦霍儿童进行了针对五种人类疱疹病毒——1型单纯疱疹病毒、2型单纯疱疹病毒、巨细胞病毒、爱泼斯坦-巴尔病毒和水痘-带状疱疹病毒——的血清抗体状况调查。为了确定人类疱疹病毒感染的严重程度，作者查阅了166名儿童的终生医疗记录，以寻找与疱疹病毒相关疾病的证据；为了阐明病毒的潜在传播方式，他们对87名儿童的家庭进行了家访。调查显示，这些儿童对1型单纯疱疹病毒（占总样本的73%）、巨细胞病毒（78%）、爱泼斯坦-巴尔病毒（98%）和水痘-带状疱疹病毒（77%）的抗体患病率很高，且患病率往往随年龄增长而增加。没有儿童显示出2型单纯疱疹病毒抗体。医疗记录显示，30%的儿童在研究前曾患过龈口炎。在控制年龄因素后，研究表明，1型单纯疱疹病毒血清阳性与婴儿期与父母同床睡觉的儿童有关（p = 0.003），也与频繁参加社区活动有关（p = 0.02）；巨细胞病毒血清阳性与女性性别有关（p = 0.007），也与居住在传统纳瓦霍住宅有关（p = 那么，007）。纳瓦霍儿童出现有症状的1型口腔单纯疱疹病毒感染的频率也高于通常记录的频率。这些发现表明某些文化行为模式与疱疹病毒感染的传播之间存在关联。
