Färber I, Sauerbrei G, Wutzler P, Weinmann G
Klin Padiatr. 1986 Nov-Dec;198(6):471-5. doi: 10.1055/s-2008-1033909.
33 children with acute lymphatic leukemia and 33 healthy controls were longitudinally studied for herpesvirus infections. Active herpes simplex-virus, varicella-zoster virus and cytomegalovirus (CMV) infections were more frequent in patients than in controls. CMV and Epstein-Barr virus infections were often inapparent or associated with infections of the upper respiratory tract. Analysis of serological datas revealed a coincidence of active CVM infection and lethal course of the leukemia. This may be a result of the immunodeficiency in leukemia patients caused by disease and therapy. An additional influence of the immunosuppressive effect of active CMV infections on the course of the disease is discussed.
对33名急性淋巴细胞白血病患儿和33名健康对照者进行了疱疹病毒感染的纵向研究。活动性单纯疱疹病毒、水痘-带状疱疹病毒和巨细胞病毒（CMV）感染在患者中比在对照者中更常见。CMV和EB病毒感染通常不明显或与上呼吸道感染有关。血清学数据分析显示，活动性CVM感染与白血病的致命病程存在巧合。这可能是疾病和治疗导致白血病患者免疫缺陷的结果。文中还讨论了活动性CMV感染的免疫抑制作用对疾病进程的额外影响。
