Molecular Psychiatry Laboratory, Hospital de Clinicas de Porto Alegre, Programa de Pós-Graduação em Psiquiatria e Ciências do Comportamento, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil.
Departamento de Psiquiatria, Universidade Federal do Paraná, Curitiba, Brazil.
Schizophr Bull. 2018 Jan 13;44(1):158-167. doi: 10.1093/schbul/sbx015.
Schizophrenia (SZ) is associated with increased somatic morbidity and mortality, in addition to cognitive impairments similar to those seen in normal aging, which may suggest that pathological accelerated aging occurs in SZ. Therefore, we aim to evaluate the relationships of age, telomere length (TL), and CCL11 (aging and inflammatory biomarkers, respectively), gray matter (GM) volume and episodic memory performance in individuals with SZ compared to healthy controls (HC). One hundred twelve participants (48 SZ and 64 HC) underwent clinical and memory assessments, structural MRI, and had their peripheral blood drawn for biomarkers analysis. Comparisons of group means and correlations were performed. Participants with SZ had decreased TL and GM volume, increased CCL11, and worse memory performance compared to HC. In SZ, shorter TL was related to increased CCL11, and both biomarkers were related to reduced GM volume, all of which were related to worse memory performance. Older age was only associated with reduced GM, but longer duration of illness was related with all the aforementioned variables. Younger age of disease onset was associated with increased CCL11 levels and worse memory performance. In HC, there were no significant correlations except between memory and GM. Our results are consistent with the hypothesis of accelerated aging in SZ. These results may indicate that it is not age itself, but the impact of the disease associated with a pathological accelerated aging that leads to impaired outcomes in SZ.
精神分裂症（SZ）与躯体发病率和死亡率增加有关，此外还存在与正常衰老相似的认知障碍，这可能表明 SZ 中存在病理性加速衰老。因此，我们旨在评估 SZ 患者与健康对照组（HC）相比，年龄、端粒长度（TL）、CCL11（分别为衰老和炎症生物标志物）、灰质（GM）体积和情景记忆表现之间的关系。112 名参与者（48 名 SZ 和 64 名 HC）接受了临床和记忆评估、结构 MRI 检查，并采集了外周血进行生物标志物分析。进行了组间均值比较和相关性分析。与 HC 相比，SZ 患者的 TL 较短，GM 体积减少，CCL11 增加，记忆表现更差。在 SZ 中，较短的 TL 与 CCL11 的增加有关，这两种生物标志物都与 GM 体积的减少有关，而这两者都与记忆表现较差有关。年龄较大仅与 GM 减少有关，但疾病持续时间较长与上述所有变量有关。发病年龄较小与 CCL11 水平升高和记忆表现较差有关。在 HC 中，除记忆与 GM 之间外，没有显著相关性。我们的结果与 SZ 加速衰老的假说一致。这些结果可能表明，导致 SZ 结果受损的不是年龄本身，而是与疾病相关的病理性加速衰老的影响。
