Salemi Rossella, Marconi Andrea, Di Salvatore Valentina, Franco Sabrina, Rapisarda Venerando, Libra Massimo
Department of Biomedical and Biotechnological Sciences, Laboratory of Translational Oncology and Functional Genomics, Section of General and Clinical Pathology and Oncology, University of Catania, I‑95123 Catania, Italy.
Section of Occupational Medicine, Department of Clinical and Experimental Medicine, University of Catania, I‑95123 Catania, Italy.
Mol Med Rep. 2017 May;15(5):3366-3371. doi: 10.3892/mmr.2017.6383. Epub 2017 Mar 24.
The chronic occupational exposure to contaminants and carcinogens leads to the development of cancer. Over the past decades, many carcinogens have been found in the occupational environment and their presence is often associated with an increased incidence of cancer. According to the International Agency for Research on Cancer (IARC), the majority of carcinogens are classified as 'probable' and 'possible' human carcinogens, while, direct evidence of carcinogenicity is provided in epidemiological and experimental studies. Additionally, accumulating evidence suggests that epigenetic alterations may be early indicators of genotoxic and non-genotoxic carcinogen exposure. In the present review, the relationship between exposures to benzene, mineral fibers, metals and epigenetic alterations are discussed as the most important cancer risk factors during work activities.
长期职业性接触污染物和致癌物会导致癌症的发生。在过去几十年里，职业环境中发现了许多致癌物，它们的存在往往与癌症发病率的上升有关。根据国际癌症研究机构（IARC）的分类，大多数致癌物被归类为“可能”和“潜在”的人类致癌物，而流行病学和实验研究提供了致癌性的直接证据。此外，越来越多的证据表明，表观遗传改变可能是遗传毒性和非遗传毒性致癌物暴露的早期指标。在本综述中，将讨论苯、矿物纤维、金属暴露与表观遗传改变之间的关系，这些是工作活动中最重要的癌症风险因素。
