College of Chemistry and Chemical Engineering, Lanzhou University , Lanzhou 730000, China.
Key Laboratory of Nonferrous Metal Chemistry and Resources Utilization of Gansu Province , Lanzhou 730000, China.
ACS Appl Mater Interfaces. 2017 Apr 12;9(14):12663-12672. doi: 10.1021/acsami.6b15746. Epub 2017 Apr 3.
Colorimetric and fluorescent dual mode detection methods have gained much attention in recent years; however, it is still desirable to develop new colorimetric and fluorescent dual mode nanosensors with more simple preparation procedures, low cost, and excellent biocompatibility. Herein, a colorimetric and fluorescent nanosensor based on B, N, S-co-doped carbon dots (BNS-CDs) was synthesized by one-step hydrothermal treatment of 2,5-diaminobenzenesulfonic acid and 4-aminophenylboronic acid hydrochloride. Using this nanosensor, a highly sensitive assay of Fe in the range of 0.3-546 μM with a detection limit of 90 nM was provided by quenching the red emission fluorescence. It is more attractive that Fe can also be visualized by this nanosensor via evident color changes of the solution (from red to blue) under sunlight without the aid of an ultraviolet (UV) lamp. Furthermore, the designed nanosensor can be applied for efficient detection of intracellular Fe with excellent biocompatibility and cellular imaging capability, and it holds great promise in biomedical applications.
近年来，比色和荧光双模检测方法受到了广泛关注；然而，开发具有更简单制备程序、低成本和优异生物相容性的新型比色和荧光双模纳米传感器仍然是可取的。在此，通过一步水热处理 2,5-二氨基苯磺酸和 4-氨基苯硼酸盐酸盐合成了基于 B、N、S 共掺杂碳点（BNS-CDs）的比色和荧光纳米传感器。使用该纳米传感器，通过猝灭红色发射荧光，提供了一个在 0.3-546 μM 范围内对 Fe 具有高灵敏度的测定，检测限为 90 nM。更有吸引力的是，Fe 还可以通过该纳米传感器在阳光下通过溶液（从红色变为蓝色）的明显颜色变化可视化，而无需紫外线（UV）灯的帮助。此外，所设计的纳米传感器可用于高效检测细胞内 Fe，具有优异的生物相容性和细胞成像能力，在生物医学应用中具有广阔的前景。
