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肿瘤患者骶髂关节肿瘤的介入性疼痛管理:病例系列及范例方法

Interventional Pain Management for Sacroiliac Tumors in the Oncologic Population: A Case Series and Paradigm Approach.

作者信息

Hutson Nathan, Hung Joseph C, Puttanniah Vinay, Lis Eric, Laufer Ilya, Gulati Amitabh

机构信息

Department of Anesthesiology, Weill Medical College, Cornell University, New York, USA.

Department of Anesthesiology and Critical Care, Memorial Sloan Kettering Cancer Center, New York, U.S.A.

出版信息

Pain Med. 2017 May 1;18(5):959-968. doi: 10.1093/pm/pnw211.

Abstract

INTRODUCTION

Tumors invading the sacrum and/or ilium often represent incurable metastatic disease, and treatment is targeted toward palliation of symptoms and control of pain. As systemic opioid therapy is frequently inadequate and limited by side effects, a variety of interventional techniques are available to better optimize analgesia. Using six patients as a paradigm for interventional approaches to pain relief, we present a therapeutic algorithm for treating sacroiliac tumor-related pain in the oncologic population.

METHODS

We describe the use of ultrasound-guided proximal sacroiliac joint corticosteroid injection, sacroiliac lateral branch radiofrequency ablation, percutaneous sacroplasty, and implantable neuraxial drug delivery devices to treat malignant sacroiliac pain in six patients. Pre- and postprocedure numerical rating scale (NRS) pain scores, duration of pain relief, and postprocedure pain medication requirements were studied for each patient.

RESULTS

Each patient had marked improvement in their pain based on an average postprocedure NRS difference of six points. The average duration of pain relief was eight months. In all cases, opioid requirements decreased after the intervention.

DISCUSSION

Depending on tumor location, burden of disease, and patient preference, patients suffering from metastatic disease to the sacrum may find benefit from use of ultrasound-guided proximal sacroiliac joint corticosteroid injection, sacroiliac lateral branch radiofrequency ablation, percutaneous sacroplasty, dorsal column stimulator leads, and/or implantable neuraxial drug delivery devices. We provide a paradigm for treatment in this patient population.

摘要

引言

侵犯骶骨和/或髂骨的肿瘤通常代表无法治愈的转移性疾病,治疗旨在缓解症状和控制疼痛。由于全身性阿片类药物治疗常常不足且受副作用限制,有多种介入技术可用于更好地优化镇痛效果。我们以6例患者作为疼痛缓解介入方法的范例,提出了一种治疗肿瘤患者骶髂关节肿瘤相关疼痛的治疗算法。

方法

我们描述了使用超声引导下骶髂关节近端皮质类固醇注射、骶髂关节外侧支射频消融、经皮骶骨成形术以及可植入式神经轴突给药装置来治疗6例患者的恶性骶髂关节疼痛。研究了每位患者术前和术后的数字评分量表(NRS)疼痛评分、疼痛缓解持续时间以及术后疼痛药物需求。

结果

每位患者的疼痛均有显著改善,术后NRS平均差异为6分。疼痛缓解的平均持续时间为8个月。在所有病例中,干预后阿片类药物需求均减少。

讨论

根据肿瘤位置、疾病负担和患者偏好,患有骶骨转移性疾病的患者可能会从使用超声引导下骶髂关节近端皮质类固醇注射、骶髂关节外侧支射频消融、经皮骶骨成形术、背柱刺激器导线和/或可植入式神经轴突给药装置中获益。我们为该患者群体提供了一种治疗范例。

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