Paolini Federica, Ferini Gianluca, Bonosi Lapo, Costanzo Roberta, Brunasso Lara, Benigno Umberto Emanuele, Porzio Massimiliano, Gerardi Rosa Maria, Giammalva Giuseppe Roberto, Umana Giuseppe Emmanuele, Graziano Francesca, Scalia Gianluca, Sturiale Carmelo Lucio, Di Bonaventura Rina, Iacopino Domenico Gerardo, Maugeri Rosario
Neurosurgical Clinic, AOUP "Paolo Giaccone", Post Graduate Residency Program in Neurologic Surgery, Department of Biomedicine Neurosciences and Advanced Diagnostics, School of Medicine, University of Palermo, 90127 Palermo, Italy.
Department of Radiation Oncology, REM Radioterapia srl, 95125 Catania, Italy.
Life (Basel). 2022 Apr 7;12(4):554. doi: 10.3390/life12040554.
(1) Background: Treatment of cancer-related pain is still challenging, and it can be managed by both medical and interventional therapies. Spinal Cord Stimulation (SCS) is a minimally invasive technique, and its use is rapidly increasing in the treatment of chronic pain. (2) Materials and Methods: Our study aims to perform a review of the pertinent literature about current evidences in cancer pain treatment by Spinal Cord Stimulation. Moreover, we created a database based on case reports or case series (18 studies) in the literature. We analyzed a clinical group of oncological patients affected by intractable pain undergoing SCS implantation, focusing on outcome. (3) Results: The analysis of the 18 included studies in our series has shown a reduction in painful symptoms in 48 out of 56 treated patients (87.51%); also 53 out of 56 patients (96.64%) have shown an improvement in their Quality of Life (QoL). (4) Conclusions: Spinal Cord Stimulation can be considered an efficient method in the treatment of cancer-related pain. However, literature regarding SCS for the treatment of cancer-related pain is largely represented by case reports and small case series, with no effective population studies or Randomized Controlled Trials demonstrating the efficacy and the level of evidence. Further prospective studies are needed.
(1) 背景：癌症相关疼痛的治疗仍然具有挑战性，可通过医学和介入疗法进行管理。脊髓刺激（SCS）是一种微创技术，其在慢性疼痛治疗中的应用正在迅速增加。(2) 材料与方法：我们的研究旨在对有关脊髓刺激治疗癌症疼痛的当前证据的相关文献进行综述。此外，我们基于文献中的病例报告或病例系列（18项研究）创建了一个数据库。我们分析了一组接受SCS植入的顽固性疼痛肿瘤患者的临床情况，重点关注治疗结果。(3) 结果：我们系列中纳入的18项研究的分析表明，56例接受治疗的患者中有48例（87.51%）疼痛症状减轻；56例患者中有53例（96.64%）生活质量得到改善。(4) 结论：脊髓刺激可被视为治疗癌症相关疼痛的一种有效方法。然而，关于SCS治疗癌症相关疼痛的文献主要以病例报告和小病例系列为主，没有有效的人群研究或随机对照试验证明其疗效和证据水平。需要进一步的前瞻性研究。
