Neuro-Oncology Branch, National Cancer Institute and National Institute of Neurological Disorders and Stroke, Bethesda, Maryland ; Surgical Neurology Branch, National Institute of Neurological Disorders and Stroke, Bethesda, Maryland.
Neuro Oncol. 2017 Jul 1;19(7):887-896. doi: 10.1093/neuonc/now258.
Glioblastoma is the most common and aggressive malignant primary brain tumor. Cellular heterogeneity is a characteristic feature of the disease and contributes to the difficulty in formulating effective therapies. Glioma stem-like cells (GSCs) have been identified as a subpopulation of tumor cells that are thought to be largely responsible for resistance to treatment. Intratumoral hypoxia contributes to maintenance of the GSCs by supporting the critical stem cell traits of multipotency, self-renewal, and tumorigenicity. This review highlights the interaction of GSCs with the hypoxic tumor microenvironment, exploring the mechanisms underlying the contribution of GSCs to tumor vessel dynamics, immune modulation, and metabolic alteration.
胶质母细胞瘤是最常见和最具侵袭性的恶性原发性脑肿瘤。细胞异质性是该疾病的一个特征，并导致难以制定有效的治疗方法。已鉴定出神经胶质瘤干细胞（GSCs）作为肿瘤细胞的一个亚群，被认为在很大程度上负责治疗耐药性。肿瘤内缺氧通过支持多能性、自我更新和致瘤性等关键干细胞特性来维持 GSCs。本文综述了 GSCs 与缺氧肿瘤微环境的相互作用，探讨了 GSCs 对肿瘤血管动力学、免疫调节和代谢改变的贡献的机制。
