反刍动物反式脂肪酸对胰岛素抵抗和2型糖尿病作用及作用机制的营养基因组学观点

Nutrigenomic point of view on effects and mechanisms of action of ruminant trans fatty acids on insulin resistance and type 2 diabetes.

作者信息

Tremblay Bénédicte L, Rudkowska Iwona

机构信息

Institute of Nutrition and Functional Foods (INAF), Laval University, Quebec City, Quebec, Canada.

Department of Endocrinology and Nephrology, CHU de Québec Research Center, Quebec City, Quebec, Canada.

出版信息

Nutr Rev. 2017 Mar 1;75(3):214-223. doi: 10.1093/nutrit/nuw066.

DOI:10.1093/nutrit/nuw066

PMID:28340087

Abstract

Evidence from observational studies suggests beneficial effects of ruminant trans fatty acids (rTFA) on insulin resistance (IR) and type 2 diabetes (T2D). However, beneficial effects of rTFA are not always observed in cell, animal, and human studies. This narrative review presents potential mechanisms of action of rTFA using nutrigenomics and microRNA results in an integrative model. In addition, the review presents factors, including measures of IR and T2D, dose and duration of studies, as well as health status, ethnicity, and genotypes of subjects, that may help explain the heterogeneity in response to rTFA supplementation. Future studies should consider these factors, as well as research in nutritional genomics, to better understand the effects of rTFA on IR and T2D.

摘要

观察性研究的证据表明反刍动物反式脂肪酸（rTFA）对胰岛素抵抗（IR）和2型糖尿病（T2D）具有有益作用。然而，在细胞、动物和人体研究中并非总能观察到rTFA的有益作用。这篇叙述性综述使用营养基因组学和microRNA结果，在一个综合模型中展示了rTFA的潜在作用机制。此外，该综述还介绍了一些因素，包括IR和T2D的测量指标、研究的剂量和持续时间，以及受试者的健康状况、种族和基因型，这些因素可能有助于解释补充rTFA后反应的异质性。未来的研究应考虑这些因素以及营养基因组学方面的研究，以更好地理解rTFA对IR和T2D的影响。