Blombach Fabian, Grohmann Dina
a RNAP Laboratory , University College London, Institute of Structural and Molecular Biology, Division of Biosciences , London , UK.
b Department of Biochemistry, Genetics and Microbiology , Institute of Microbiology, University of Regensburg , Regensburg , Germany.
Transcription. 2017 May 27;8(3):162-168. doi: 10.1080/21541264.2017.1289879. Epub 2017 Feb 8.
Transcription factors TBP and TF(II)B assemble with RNA polymerase at the promoter DNA forming the initiation complex. Despite a high degree of conservation, the molecular binding mechanisms of archaeal and eukaryotic TBP and TF(II)B differ significantly. Based on recent biophysical data, we speculate how the mechanisms co-evolved with transcription regulation and TBP multiplicity.
转录因子TBP和TF(II)B与RNA聚合酶在启动子DNA处组装，形成起始复合物。尽管具有高度保守性，但古细菌和真核生物的TBP和TF(II)B的分子结合机制存在显著差异。基于最近的生物物理数据，我们推测了这些机制是如何与转录调控和TBP多样性共同进化的。
