Duttke Sascha H C
Section of Molecular Biology, University of California, San Diego, La Jolla, CA 92093, USA.
Trends Biochem Sci. 2015 Mar;40(3):127-9. doi: 10.1016/j.tibs.2015.01.005. Epub 2015 Feb 5.
Transcription initiation was once thought to be regulated primarily by sequence-specific transcription factors with the basal transcription machinery being largely invariant. Gradually it became apparent that the basal transcription machinery greatly diversified during evolution and new studies now demonstrate that diversification of the TATA-binding protein (TBP) family yielded specialized and largely independent transcription systems.
转录起始曾被认为主要由序列特异性转录因子调控,而基础转录机制在很大程度上是不变的。逐渐地,人们发现基础转录机制在进化过程中发生了极大的分化,现在新的研究表明,TATA结合蛋白(TBP)家族的分化产生了专门的且在很大程度上独立的转录系统。