Division of Molecular Genetics, the Netherlands Cancer Institute, Amsterdam, the Netherlands.
Division of Molecular Genetics, the Netherlands Cancer Institute, Amsterdam, the Netherlands.
Cell. 2017 Mar 23;169(1):3-5. doi: 10.1016/j.cell.2017.03.014.
In this issue of Cell, Baar et al. show how FOXO4 protects senescent cell viability by keeping p53 sequestered in nuclear bodies, preventing it from inducing apoptosis. Disrupting this interaction with an all-D amino acid peptide (FOXO4-DRI) restores p53's apoptotic role and ameliorates the consequences of senescence-associated loss of tissue homeostasis.
在本期《细胞》杂志上，Baar 等人展示了 FOXO4 如何通过将 p53 隔离在核体内来保护衰老细胞的活力，从而防止其诱导细胞凋亡。用全 D 氨基酸肽（FOXO4-DRI）破坏这种相互作用可以恢复 p53 的凋亡作用，并改善与衰老相关的组织内稳态丧失的后果。
