Torelli S, Masoudi F, Prasad K N
Department of Radiology, College of Medicine, University of Colorado Health Sciences Center, Denver 80262.
Cancer Lett. 1988 Mar;39(2):129-36. doi: 10.1016/0304-3835(88)90097-3.
d-Alpha tocopheryl succinate (vitamin E succinate), which inhibited growth and survival, and induced differentiation in murine B-16 melanoma cells in culture, increased adenosine 3',5'cyclic monophosphate-(cAMP)-dependent protein kinase (PK) activity without increasing the cellular cAMP level. Prostaglandin (PG)A2, which produced changes in melanoma cells similar to those produced by vitamin E succinate, also increased cAMP-dependent PK activity without changing the intracellular level of cAMP.
琥珀酸d-α生育酚（维生素E琥珀酸酯）可抑制培养的小鼠B-16黑色素瘤细胞的生长和存活并诱导其分化，它能增加3',5'-环磷酸腺苷（cAMP）依赖性蛋白激酶（PK）的活性，而不提高细胞内cAMP水平。前列腺素（PG）A2对黑色素瘤细胞产生的作用与维生素E琥珀酸酯类似，它同样能增加cAMP依赖性PK的活性，而不改变细胞内cAMP水平。
