Winther K, Trap-Jensen J
Department of Clinical Chemistry, Frederiksberg Hospital, Denmark.
Clin Physiol. 1988 Apr;8(2):147-53. doi: 10.1111/j.1475-097x.1988.tb00203.x.
Plasma levels of adrenaline and noradrenaline, platelet cyclic-AMP (cAMP) content, platelet aggregation, platelet release of beta-thromboglobulin, and platelet factor 4 and serum content of thromboxane B2(TXB2) and 6-keto-PGF1 alpha were measured in 12 healthy male volunteers (age 38-72, mean 54.2 years) who were tested at rest and immediately after five min light cycle exercise. The plasma levels of adrenaline and noradrenaline increased significantly after exercise (P less than 0.01). The platelet cAMP level was not changed by exercise. The functional capacity of platelet beta-adrenoceptors, determined as cAMP production after beta-adrenoceptor stimulation in vitro, decreased highly significantly after exercise in all 12 volunteers (P less than 0.01). No alteration was observed in platelet aggregation induced by adrenaline or in platelet release of beta-thromboglobulin or platelet factor 4. No change was observed in the serum levels of TXB2 and 6-keto-PGF1 alpha.
light cycle exercise results in a decreased functional capacity of platelet beta-adrenoceptors, but has no effect on platelet aggregation or platelet release. This might indicate a concomitant and equal decreased functional capacity of platelet alpha-adrenoceptors.
对12名健康男性志愿者（年龄38 - 72岁，平均54.2岁）在静息状态下以及进行5分钟轻度循环运动后立即进行检测，测量血浆肾上腺素和去甲肾上腺素水平、血小板环磷酸腺苷（cAMP）含量、血小板聚集、血小板β - 血小板球蛋白释放、血小板因子4以及血栓素B2（TXB2）和6 - 酮 - 前列腺素F1α的血清含量。运动后血浆肾上腺素和去甲肾上腺素水平显著升高（P < 0.01）。运动后血小板cAMP水平未发生变化。通过体外β - 肾上腺素能受体刺激后cAMP生成所测定的血小板β - 肾上腺素能受体功能能力，在所有12名志愿者运动后均高度显著降低（P < 0.01）。肾上腺素诱导的血小板聚集、血小板β - 血小板球蛋白或血小板因子4的释放未观察到改变。TXB2和6 - 酮 - 前列腺素F1α的血清水平未观察到变化。
轻度循环运动导致血小板β - 肾上腺素能受体功能能力降低，但对血小板聚集或血小板释放无影响。这可能表明血小板α - 肾上腺素能受体功能能力同时且同等程度降低。
