Gleerup G, Winther K
Department of Clinical Chemistry, Frederiksberg Hospital, Copenhagen, Denmark.
Eur J Clin Invest. 1988 Oct;18(5):504-6. doi: 10.1111/j.1365-2362.1988.tb01047.x.
Twelve healthy young volunteers (mean age 21, range 18-27 years) and 12 elderly people (mean age 77, range 72-86 years) were tested regarding platelet aggregation induced by adrenaline, ADP and serotonin. The serum levels of thromboxane B2 (TXB2) and serum 6-keto-PGF1 alpha and the plasma level of adrenaline and cyclic AMP (cAMP) were also measured. Platelet aggregation induced by adrenaline and ADP increased significantly in the elderly compared with the young group (P less than 0.05 and P less than 0.02, respectively). There was a substantial and highly significant increase in the response of platelets from elderly people to serotonin (P less than 0.01). No alteration was observed in the serum level of TXB2 or 6-keto-PGF1 alpha. Plasma adrenaline increased in the old group, but plasma cAMP was unaffected. As serotonin is known to amplify adrenaline- and ADR-induced platelet aggregation, the considerable increase in platelet sensitivity to serotonin could be an important factor in the increased adrenaline and ADP-induced platelet aggregability of elderly people.
对12名健康年轻志愿者（平均年龄21岁，年龄范围18 - 27岁）和12名老年人（平均年龄77岁，年龄范围72 - 86岁）进行了关于肾上腺素、二磷酸腺苷（ADP）和5-羟色胺（血清素）诱导的血小板聚集的测试。还测量了血栓素B2（TXB2）的血清水平、血清6-酮-前列腺素F1α以及肾上腺素和环磷酸腺苷（cAMP）的血浆水平。与年轻组相比，老年人中由肾上腺素和ADP诱导的血小板聚集显著增加（分别为P < 0.05和P < 0.02）。老年人血小板对血清素的反应有大幅且极显著的增加（P < 0.01）。未观察到TXB2或6-酮-前列腺素F1α的血清水平有变化。老年组血浆肾上腺素增加，但血浆cAMP未受影响。由于已知血清素会增强肾上腺素和ADP诱导的血小板聚集，血小板对血清素敏感性的显著增加可能是老年人肾上腺素和ADP诱导的血小板聚集性增加的一个重要因素。
