Hedman C, Winther K, Knudsen J B
Department of Clinical Pharmacology, University of Gothenburg, Sweden.
Acta Neurol Scand. 1988 Oct;78(4):271-7. doi: 10.1111/j.1600-0404.1988.tb03656.x.
It has been reported that migraine sufferers have an enhanced platelet activity, as well as an enhanced thromboembolic risk. In this study, 12 subjects with classic migraine were compared with 12 age- and sex-matched controls. The following parameters were tested: platelet aggregation; platelet content of ADP, ATP and cyclic-AMP (cAMP); plasma levels of cAMP, 6-keto-PGF1 alpha and thromboxane B2, serum levels of TxB2 and lipids. ADP- and adrenaline-induced platelet aggregation, platelet content of ADP, ATP and cAMP did not differ significantly between the groups. Platelets from migraine subjects, however, showed a decreased beta-adrenoceptor response to stimulation with isoprenaline when determined as platelet cAMP production in vitro. The prostacyclin metabolite 6-keto-PGF 1 alpha was significantly decreased in the migraine group. No difference were observed in TxB2. Plasma lipids were similar, except that the migraine cases had higher levels of LDL-cholesterol. These data do not confirm a general platelet malfunction in migraine patients, but suggest a decreased functional capacity of platelet beta-adrenoceptors and an altered metabolism of prostacyclin and LDL-cholesterol.
据报道，偏头痛患者的血小板活性增强，血栓栓塞风险也增加。在本研究中，将12名典型偏头痛患者与12名年龄和性别匹配的对照者进行了比较。测试了以下参数：血小板聚集；血小板中ADP、ATP和环磷酸腺苷（cAMP）的含量；血浆中cAMP、6-酮-前列环素F1α和血栓素B2的水平，血清中血栓素B2和脂质的水平。两组之间，ADP和肾上腺素诱导的血小板聚集、血小板中ADP、ATP和cAMP的含量没有显著差异。然而，当在体外测定血小板cAMP生成时，偏头痛患者的血小板对异丙肾上腺素刺激的β-肾上腺素能受体反应降低。偏头痛组中前列环素代谢产物6-酮-前列环素F1α显著降低。血栓素B2未观察到差异。血浆脂质相似，只是偏头痛患者的低密度脂蛋白胆固醇水平较高。这些数据并未证实偏头痛患者普遍存在血小板功能障碍，但提示血小板β-肾上腺素能受体的功能能力降低，以及前列环素和低密度脂蛋白胆固醇的代谢改变。
