Dieckmann K P, Düe W, Bauknecht K J, Hamm B
Urologische Klinik, Freie Universität Berlin.
Dtsch Med Wochenschr. 1988 Apr 15;113(15):598-601. doi: 10.1055/s-2008-1067689.
A space-occupying mediastinal mass was discovered in a 16-year-old boy with metastasizing non-seminomatous testicular tumour six months after successful conclusion of cytostatic chemotherapy. Metastases at other sites were excluded. An enlarged thymus was the only finding at operation. Histological and histochemical examination demonstrated diffuse hyperplasia. The findings demonstrate that reactive benign thymic hyperplasia after cytostatic chemotherapy has to be considered in the differential diagnosis of space-occupying mediastinal lesions. They can also occur in adults. They are benign, explainable as immunological rebound phenomena, and do not require operative intervention. In case of doubt, short-term corticoid administration will diminish the size of the mass and thus confirms the diagnosis.
一名16岁男孩在成功完成细胞毒性化疗6个月后，被发现患有纵隔占位性肿块，其患有转移性非精原细胞瘤性睾丸肿瘤。排除了其他部位的转移。手术中唯一的发现是胸腺肿大。组织学和组织化学检查显示为弥漫性增生。这些发现表明，在纵隔占位性病变的鉴别诊断中，必须考虑细胞毒性化疗后反应性良性胸腺增生。它们也可发生于成年人。它们是良性的，可解释为免疫反弹现象，不需要手术干预。如有疑问，短期给予皮质类固醇会使肿块缩小，从而证实诊断。
