Rüther U, Müller H A, Nunnensiek C, Rupp W, Bader H, Fauser L
Abteilung für Allgemeine Innere Medizin, Katharinen-hospital, Stuttgart.
Med Klin (Munich). 1990 Feb 15;85(2):72-7.
Follow-up serial computed tomographic scans of 124 patients treated for testicular cancer with either radiotherapy or retroperitoneal lymphadenectomy alone or in combination with chemotherapy were evaluated. Thymic enlargement occurred three to 20 months after initiation of treatment in 15 of the 124 patients. Thymic enlargement could histopathologically be demonstrated in seven patients as true hyperplasia. One of these seven patients however had evidence of metastatic disease with thymic infiltration by a malignant teratoma. Thus it may be impossible to distinguish benign thymus hyperplasia from tumor-infiltration on the basis of ct information alone and sternotomy may be required. No severe defect of cellular immunity could be found. There is no specific constellation of lymphocytic markers in peripheral blood which could indicate true thymic hyperplasia.
对124例接受单纯放疗或腹膜后淋巴结清扫术或联合化疗治疗的睾丸癌患者进行了系列随访计算机断层扫描评估。124例患者中有15例在治疗开始后3至20个月出现胸腺肿大。7例患者经组织病理学证实胸腺肿大为真性增生。然而，这7例患者中有1例有转移性疾病的证据，恶性畸胎瘤浸润胸腺。因此，仅根据CT信息可能无法区分良性胸腺增生和肿瘤浸润，可能需要进行胸骨切开术。未发现严重的细胞免疫缺陷。外周血中没有特定的淋巴细胞标志物组合可以表明真性胸腺增生。
