Department of Dermatology, University Hospital Jena, Erfurter Straße 35, Jena, 07743, Germany.
Am J Clin Dermatol. 2017 Oct;18(5):629-642. doi: 10.1007/s40257-017-0278-9.
Primary localized cutaneous amyloidosis (PLCA) is characterized by extracellular deposition of heterogenic amyloid proteins in the skin without systemic involvement. Lichen amyloidosis, macular amyloidosis, and (primary localized cutaneous) nodular amyloidosis are different subtypes of PLCA.
The aim of this study was to review the current reported treatment options for PLCA.
This systematic review was based on a search in the PubMed database for English and German articles from 1985 to 2016.
Reports on the treatment of PLCA were limited predominantly to case reports or small case series. There were a few clinical trials but these lacked control groups. A variety of treatment options for PLCA were reported including retinoids, corticosteroids, cyclophosphamide, cyclosporine, amitriptyline, colchicine, cepharanthin, tacrolimus, dimethyl sulfoxide, vitamin D analogs, capsaicin, menthol, hydrocolloid dressings, surgical modalities, laser treatment, and phototherapy.
No definitive recommendation of preferable treatment procedures can be made based on the analyzed literature. Randomized controlled trials are needed to offer patients an evidence-based therapy with high-quality standardized treatment regimens for PLCA.
原发性皮肤局限性淀粉样变（PLCA）的特征是皮肤内细胞外沉积异质淀粉样蛋白，而无全身受累。苔藓样淀粉样变、斑状淀粉样变和（原发性皮肤局限性）结节状淀粉样变为 PLCA 的不同亚型。
本研究旨在综述 PLCA 的现有治疗选择。
本系统评价基于对 1985 年至 2016 年发表的英文和德文文献的 PubMed 数据库检索。
关于 PLCA 治疗的报告主要限于病例报告或小病例系列。虽然有一些临床试验，但缺乏对照组。报道了多种治疗 PLCA 的选择，包括维甲酸、皮质类固醇、环磷酰胺、环孢素、阿米替林、秋水仙碱、石蒜碱、他克莫司、二甲基亚砜、维生素 D 类似物、辣椒素、薄荷醇、水胶体敷料、手术方式、激光治疗和光疗。
根据分析的文献，不能对首选治疗方案做出明确的推荐。需要进行随机对照试验，为患者提供基于证据的治疗，制定高质量的 PLCA 标准化治疗方案。
