Veterans Affairs New England Mental Illness, Research, Education, and Clinical Center, 950 Campbell Ave., 151D, West Haven, CT, 06516, USA.
Department of Psychiatry, Yale School of Medicine, New Haven, CT, USA.
Psychiatr Q. 2017 Dec;88(4):909-916. doi: 10.1007/s11126-017-9508-9.
There have been few epidemiological studies exploring the link between PTSD and inflammation using population-based samples. This study examined the relation between posttraumatic stress disorder (PTSD) and inflammation-related medical conditions using data from the 2013-2014 New York City Health and Nutrition Examination Survey. Using a representative sample of 1,527 residents in New York City, the association between PTSD and 17 inflammation-related medical conditions were examined. Bivariate and multivariable analyses were conducted, adjusting for demographic characteristics and lifetime depression. PTSD was strongly associated with increased odds for hypercholesterolemia, insulin resistance, angina, heart attack, and emphysema with the greatest odds observed for heart attack (OR= 3.94) and emphysema (OR= 4.06). But PTSD was also associated with lower odds for hypertension, type 1 diabetes, asthma, coronary heart disease, stroke, osteoporosis, and a failing kidney with the lowest odds observed for type 1 diabetes (OR= 0.43). These findings suggest a complex link between PTSD and inflammation-related medical conditions.
使用基于人群的样本，很少有流行病学研究探索 PTSD 和炎症之间的联系。本研究使用 2013-2014 年纽约市健康和营养检查调查的数据，研究了创伤后应激障碍（PTSD）与炎症相关医疗状况之间的关系。使用纽约市 1527 名居民的代表性样本，检查了 PTSD 与 17 种炎症相关医疗状况之间的关联。进行了双变量和多变量分析，调整了人口统计学特征和终生抑郁。PTSD 与高胆固醇血症、胰岛素抵抗、心绞痛、心脏病发作和肺气肿的患病几率增加密切相关，心脏病发作（OR=3.94）和肺气肿（OR=4.06）的几率最高。但 PTSD 也与高血压、1 型糖尿病、哮喘、冠心病、中风、骨质疏松症和肾脏衰竭的患病几率降低相关，1 型糖尿病（OR=0.43）的几率最低。这些发现表明 PTSD 和炎症相关医疗状况之间存在复杂的联系。
