Bogdanov E G
Biull Eksp Biol Med. 1989 Sep;108(9):309-11.
It has been demonstrated in experiments on unrestrained and unanesthetized curarized cats that periaqueductal gray matter stimulation produce sympathetic-activating action, raise arterial pressure and heart rate, but at the same time is not effective enough to suppress the nociceptive shifts of haemodynamic reactions. Opioid mechanisms of spinal cord plays an essential role in sympathetic-activating action of periaqueductal gray matter. It is suggested that the influence of antinociceptive areas of the brain stem on sympathetic haemodynamic regulation is one of the causes of resistance of nociceptive haemodynamic reactions to narcotic analgetics.
在对未受束缚、未麻醉且使用箭毒的猫进行的实验中已证明,中脑导水管周围灰质刺激会产生交感神经激活作用,升高动脉血压和心率,但同时在抑制血流动力学反应的伤害性变化方面效果不够显著。脊髓的阿片类机制在中脑导水管周围灰质的交感神经激活作用中起重要作用。有人提出,脑干抗伤害感受区域对交感神经血流动力学调节的影响是伤害性血流动力学反应对麻醉性镇痛药产生抵抗的原因之一。