Al Saud Aljoharah, Alsergani Reem, Alhumidi Ahmed, Aleisa Abdullah
College of Medicine, Alfaisal University, Riyadh, Saudi Arabia.
Department of Dermatology, College of Medicine, King Saud University Medical City (KSUMC), Riyadh, Saudi Arabia.
Case Rep Dermatol. 2025 Jan 27;17(1):68-73. doi: 10.1159/000543349. eCollection 2025 Jan-Dec.
Anaplastic large cell lymphomas (ALCL) are a subtype of non-Hodgkin lymphoma categorized into systemic and cutaneous (cALCL) subtypes. cALCL are frequently characterized by their lack of ALK receptor expression, which differentiates them from their systemic counterparts. cALCLs present as solitary or grouped skin lesions. Due to their rarity, cALCLs are frequently misdiagnosed as other skin conditions.
We report the case of a female with a 30-year history of expanding skin lesions on the upper and lower limbs, abdomen, and back. During her initial presentation, the lesions were thought to be due to an arthropod bite. However, lesion biopsy revealed ALK-negative cALCL and methicillin-resistant A full workup excluded systemic ALCL and, therefore, confirmed the diagnosis of primary cALCL. The patient was placed on methotrexate to treat the lesions and sulfamethoxazole/trimethoprim to treat the infection.
Our case highlights the need to consider cALCL in the differential diagnosis of patients with persistent skin lesions.
间变性大细胞淋巴瘤（ALCL）是非霍奇金淋巴瘤的一种亚型，分为系统性和皮肤型（cALCL）亚型。cALCL的特征通常是缺乏ALK受体表达，这使其与系统性ALCL有所区别。cALCL表现为孤立或成群的皮肤病变。由于其罕见性，cALCL常被误诊为其他皮肤疾病。
我们报告一例女性患者，其上肢、下肢、腹部和背部出现逐渐扩大的皮肤病变已有30年病史。在其初次就诊时，这些病变被认为是节肢动物叮咬所致。然而，病变活检显示为ALK阴性的cALCL以及耐甲氧西林……全面检查排除了系统性ALCL，因此确诊为原发性cALCL。该患者接受甲氨蝶呤治疗病变，并使用磺胺甲恶唑/甲氧苄啶治疗感染。
我们的病例强调在对持续性皮肤病变患者进行鉴别诊断时需要考虑cALCL。
