计算机断层扫描在肝硬化患者肝细胞癌筛查中的作用。

Role of computed tomography in screening for hepatocellular carcinoma in patients with cirrhosis.

作者信息

Henderson J M, Campbell J D, Olson R, Nelson R C

机构信息

Department of Surgery, Emory University School of Medicine, Atlanta, Georgia 30322.

出版信息

Gastrointest Radiol. 1988;13(2):129-34. doi: 10.1007/BF01889041.

DOI:10.1007/BF01889041

PMID:2834256

Abstract

One hundred patients with cirrhosis underwent abdominal computed tomography (CT) using a delayed contrast technique to determine liver and spleen volume. These scans were reviewed to screen this "at risk" population for hepatocellular carcinoma (HCC). Fifteen of the 100 screened patients had focal abnormalities suspicious for HCC. On biopsy, only 1 patient was shown to have HCC. The other 14 patients had either fatty infiltration or focal regeneration. In the same time interval, a total of 10 patients had histologically proven HCC. All presented with symptoms and died within 4 months of diagnosis. The results show that focal hepatic lesions can be detected by CT but in this population the lesions may not be due to HCC. The incidence of HCC was approximately 1%, probably reflecting a truly low incidence in this population.

摘要

100例肝硬化患者接受了腹部计算机断层扫描（CT），采用延迟造影技术来测定肝脏和脾脏体积。对这些扫描结果进行复查，以筛查这一“高危”人群中的肝细胞癌（HCC）。在接受筛查的100例患者中，有15例存在可疑为HCC的局灶性异常。经活检，仅1例患者被证实患有HCC。其他14例患者要么有脂肪浸润，要么有局灶性再生。在同一时间段内，共有10例患者经组织学证实患有HCC。所有患者均出现症状，并在诊断后4个月内死亡。结果表明，CT可检测出肝脏局灶性病变，但在这一人群中，这些病变可能并非由HCC引起。HCC的发病率约为1%，这可能反映了该人群中真正的低发病率。