Sepúlveda Cesar, Palomo Iván, Fuentes Eduardo
Platelet Research Laboratory, Department of Clinical Biochemistry and Immunohaematology, Faculty of Health Sciences, Interdisciplinary Excellence Research Program on Healthy Aging (PIEI-ES), Universidad de Talca, Talca, Chile.
Platelet Research Laboratory, Department of Clinical Biochemistry and Immunohaematology, Faculty of Health Sciences, Interdisciplinary Excellence Research Program on Healthy Aging (PIEI-ES), Universidad de Talca, Talca, Chile.
Vascul Pharmacol. 2017 Apr;91:10-17. doi: 10.1016/j.vph.2017.03.004. Epub 2017 Mar 22.
Beyond its function in hemostasis, platelets activation has an important role in cardiovascular diseases (CVD) development. There are different clinical conditions that can mediate abnormal platelet activation and favors pathological thrombosis and CVD. These include Hypertension, diabetes and dyslipidemia, all risks factors from CVD development. Different drugs employed in the handled of these conditions have showed decreases platelet activation and related markers. This effect is in part by improved the base condition; however someone of these drugs can modulate platelet targets. We discuss about underlying mechanisms and the possible implications in the treatment of CVD.
除了在止血方面的功能外，血小板活化在心血管疾病（CVD）的发展中起着重要作用。有不同的临床情况可介导异常的血小板活化，并促进病理性血栓形成和心血管疾病。这些情况包括高血压、糖尿病和血脂异常，所有这些都是心血管疾病发展的危险因素。用于治疗这些疾病的不同药物已显示出可降低血小板活化及相关标志物。这种作用部分是通过改善基础状况实现的；然而，这些药物中的一些可以调节血小板靶点。我们将讨论其潜在机制以及在心血管疾病治疗中的可能意义。
