Tokusumi Yumiko, Tokusumi Tsuyoshi, Schulz Robert A
Department of Biological Sciences, University of Notre Dame, Notre Dame, IN 46556, USA.
Department of Biological Sciences, University of Notre Dame, Notre Dame, IN 46556, USA.
Biochem Biophys Res Commun. 2017 May 13;486(4):893-897. doi: 10.1016/j.bbrc.2017.03.116. Epub 2017 Mar 22.
In vertebrates, interaction between the nervous system and immune system is important to protect a challenged host from stress inputs from external sources. In this study, we demonstrate that sensory neurons are involved in the cellular immune response elicited by wasp infestation of Drosophila larvae. Multidendritic class IV neurons sense contacts from external stimuli and induce avoidance behaviors for host defense. Our findings show that inactivation of these sensory neurons impairs the cellular response against wasp parasitization. We also demonstrate that the nociception genes encoding the mechanosensory receptors Painless and Piezo, both expressed in class IV neurons, are essential for the normal cellular immune response to parasite challenge.
在脊椎动物中，神经系统与免疫系统之间的相互作用对于保护受挑战的宿主免受外部应激源的影响至关重要。在本研究中，我们证明感觉神经元参与了果蝇幼虫被黄蜂侵袭所引发的细胞免疫反应。多树突状IV类神经元感知来自外部刺激的接触并诱导宿主防御的回避行为。我们的研究结果表明，这些感觉神经元的失活会损害针对黄蜂寄生的细胞反应。我们还证明，编码机械感觉受体Painless和Piezo的伤害感受基因，均在IV类神经元中表达，对于寄生虫攻击的正常细胞免疫反应至关重要。
