McCully James D, Cowan Douglas B, Emani Sitaram M, Del Nido Pedro J
Department of Cardiac Surgery, Boston Children's Hospital, Boston, MA, USA; Harvard Medical School, Boston, MA, USA.
Department of Anesthesiology, Perioperative and Pain Medicine, Boston Children's Hospital, Boston, MA, USA; Harvard Medical School, Boston, MA, USA.
Mitochondrion. 2017 May;34:127-134. doi: 10.1016/j.mito.2017.03.004. Epub 2017 Mar 22.
Mitochondrial transplantation is a novel therapeutic intervention to treat ischemia/reperfusion related disorders. The method for mitochondrial transplantation is simple and rapid and can be delivered to the end organ either by direct injection or vascular infusion. In this review, we provide mechanistic and histological studies in large animal models and present data to show clinical efficacy in human patients.
线粒体移植是一种治疗缺血/再灌注相关疾病的新型治疗干预措施。线粒体移植方法简单快捷，可通过直接注射或血管灌注将其递送至终末器官。在本综述中，我们提供了大型动物模型的机制和组织学研究，并展示了在人类患者中的临床疗效数据。
