Rana Tanha Ashok, Prajapati Akhilesh
Department of Life Sciences, Biotechnology Division, School of Science, GSFC University, Vadodara 391750, Gujarat, India.
World J Clin Oncol. 2025 Jul 24;16(7):107788. doi: 10.5306/wjco.v16.i7.107788.
New approaches in cancer treatment are increasingly emphasizing innovative biological processes such as ferroptosis, autophagy, and mitochondrial dynamics. Ferroptosis, characterized by iron-dependent lipid peroxidation, has emerged as a promising strategy for targeting aggressive and metastatic cancers including those of the lung, breast, prostate, pancreas, and colorectal regions. Autophagy, a cellular degradation mechanism, plays a dual role in cancer-it can inhibit tumor development by clearing damaged cellular components or, paradoxically, support tumor growth under stressful conditions. Mitochondrial dynamics, encompassing the continuous processes of fission and fusion, are often disrupted in various types of human cancers, leading to altered metabolism, therapy resistance, and metastasis. These disruptions make them favorable targets for innovative treatments. This review highlights ferroptosis as a novel form of cell death, focusing on its biological pathways and connections with mitochondrial dysfunction and autophagy. Understanding the interplay among these three mechanisms in the complex biology of cancer could provide a more comprehensive and effective approach to cancer therapy.
癌症治疗的新方法越来越强调诸如铁死亡、自噬和线粒体动力学等创新生物学过程。铁死亡以铁依赖性脂质过氧化为特征，已成为一种有前景的策略，用于靶向侵袭性和转移性癌症，包括肺癌、乳腺癌、前列腺癌、胰腺癌和结直肠癌。自噬是一种细胞降解机制，在癌症中发挥双重作用——它可以通过清除受损的细胞成分来抑制肿瘤发展，或者在压力条件下反常地支持肿瘤生长。线粒体动力学包括持续的裂变和融合过程，在各种类型的人类癌症中经常被破坏，导致代谢改变、治疗抵抗和转移。这些破坏使它们成为创新治疗的有利靶点。本综述强调铁死亡是一种新型细胞死亡形式，重点关注其生物学途径以及与线粒体功能障碍和自噬的联系。了解这三种机制在癌症复杂生物学中的相互作用，可为癌症治疗提供更全面、有效的方法。
