Połczyńska Monika M, Japardi Kevin, Bookheimer Susan Y
Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine at UCLA, University of California, Los Angeles, CA, USA; Faculty of English, Adam Mickiewicz University, Poznań, Poland.
Department of Psychiatry and Biobehavioral Sciences, David Geffen School of Medicine at UCLA, University of California, Los Angeles, CA, USA.
Brain Lang. 2017 Jul;170:1-11. doi: 10.1016/j.bandl.2017.03.002. Epub 2017 Mar 23.
Research on bilinguals with brain lesions is complicated by high patient variability, making it difficult to find well-matched controls. We benefitted from a database of over 700 patients and conducted an analysis of pre-operative functional magnetic resonance imaging data to assess language dominance in 25 early, highly proficient Spanish-English bilinguals, and 25 carefully matched monolingual controls. Our results showed that early bilingualism is associated with greater bilateral hemispheric involvement, and monolingualism is associated with stronger left hemisphere lateralization (p=0.009). The bilinguals showed more pronounced right hemisphere activation (p=0.008). Although language dominance values were concordant in the bilingual group, there were a few (12%) atypical cases with different lateralization patterns in L1 and L2. Finally, we found distinct areas of activity in first and second language within the language network, in addition to regions of convergence. These data underscore the need to map all languages proficiently spoken by surgical candidates.
对患有脑部损伤的双语者进行研究因患者个体差异较大而变得复杂，这使得难以找到匹配良好的对照组。我们受益于一个包含700多名患者的数据库，并对术前功能磁共振成像数据进行了分析，以评估25名早期、精通西班牙语和英语的双语者以及25名精心匹配的单语对照组的语言优势情况。我们的结果表明，早期双语与双侧半球更大程度的参与有关，而单语则与更强的左半球侧化有关（p = 0.009）。双语者表现出更明显的右半球激活（p = 0.008）。尽管双语组的语言优势值是一致的，但仍有少数（12%）非典型病例在第一语言和第二语言中表现出不同的侧化模式。最后，除了汇聚区域外，我们还在语言网络中发现了第一语言和第二语言各自不同的活动区域。这些数据强调了对手术候选人熟练掌握的所有语言进行映射的必要性。
