Weber Stephanie C
Department of Biology, McGill University, Montreal, QC H3A 1B1, Canada.
Curr Opin Cell Biol. 2017 Jun;46:62-71. doi: 10.1016/j.ceb.2017.03.003. Epub 2017 Mar 23.
Concomitant with packaging the genome, the cell nucleus must also spatially organize the nucleoplasm. This complex mixture of proteins and nucleic acids partitions into a variety of phase-separated, membraneless organelles called nuclear bodies. Significant progress has been made in understanding the relationship between the material properties of nuclear bodies and their structural and functional consequences. Furthermore, the molecular basis of these condensed phases is beginning to emerge. Here, I review the latest work in this exciting field, highlighting recent advances and new challenges.
在包装基因组的同时，细胞核还必须在空间上组织核质。这种蛋白质和核酸的复杂混合物会分隔成各种相分离的无膜细胞器，称为核体。在理解核体的物质特性与其结构和功能后果之间的关系方面已经取得了重大进展。此外，这些凝聚相的分子基础也开始显现。在这里，我回顾了这个令人兴奋的领域的最新工作，重点介绍了最近的进展和新挑战。
