Staněk David, Fox Archa H
Institute of Molecular Genetics, Czech Academy of Sciences, Prague, Czech Republic.
School of Human Sciences and Molecular Sciences, The University of Western Australia and Harry Perkins Institute of Medical Research, Centre for Medical Research, The University of Western Australia, Crawley, 6009 Western Australia, Australia.
Curr Opin Cell Biol. 2017 Jun;46:94-101. doi: 10.1016/j.ceb.2017.05.001. Epub 2017 May 31.
The cell nucleus contains a number of different dynamic bodies that are variously composed of proteins and generally, but not always, specific RNA molecules. Recent studies have revealed new understanding about nuclear body formation and function in different aspects of nuclear metabolism. Here, we focus on findings describing the role of nuclear bodies in the biogenesis of specific ribonucleoprotein complexes, processing of key mRNAs, and subnuclear sequestration of protein factors. We highlight how nuclear bodies are involved in stress responses, innate immunity and tumorigenesis. We further review organization of nuclear bodies and principles that govern their assembly, highlighting the pivotal role of scaffolding noncoding RNAs, and liquid-liquid phase separation, which are transforming our picture of nuclear body formation.
细胞核包含许多不同的动态结构，这些结构由蛋白质以各种方式组成，并且通常（但并非总是）包含特定的RNA分子。最近的研究揭示了关于核体在核代谢不同方面的形成和功能的新认识。在这里，我们关注描述核体在特定核糖核蛋白复合物生物合成、关键mRNA加工以及蛋白质因子亚核隔离中的作用的研究结果。我们强调核体如何参与应激反应、先天免疫和肿瘤发生。我们进一步回顾核体的组织以及控制其组装的原则，突出支架非编码RNA和液-液相分离的关键作用，这些正在改变我们对核体形成的认识。
