Cioce Mario, Lamond Angus I
IRBM (Merck Research Laboratories Rome), Rome, Italy.
Annu Rev Cell Dev Biol. 2005;21:105-31. doi: 10.1146/annurev.cellbio.20.010403.103738.
This review surveys what is known about the structure and function of the subnuclear domains called Cajal bodies (CBs). The major focus is on CBs in mammalian cells but we provide an overview of homologous CB structures in other organisms. We discuss the protein and RNA components of CBs, including factors recently found to associate in a cell cycle-dependent fashion or under specific metabolic or stress conditions. We also consider the dynamic properties of both CBs and their molecular components, based largely on recent data obtained thanks to the advent of improved in vivo detection and imaging methods. We discuss how these data contribute to an understanding of CB functions and highlight major questions that remain to be answered. Finally, we consider the interesting links that have emerged between CBs and alterations in nuclear structure apparent in a range of human pathologies, including cancer and inherited neurodegenerative diseases. We speculate on the relationship between CB function and molecular disease.
本综述探讨了关于名为卡哈尔体（CBs）的亚核结构域的结构和功能的已知信息。主要关注哺乳动物细胞中的卡哈尔体，但我们也概述了其他生物体中的同源卡哈尔体结构。我们讨论了卡哈尔体的蛋白质和RNA成分，包括最近发现的以细胞周期依赖性方式或在特定代谢或应激条件下相互关联的因子。我们还基于因改进的体内检测和成像方法的出现而获得的最新数据，考虑了卡哈尔体及其分子成分的动态特性。我们讨论了这些数据如何有助于理解卡哈尔体的功能，并突出了仍有待解答的主要问题。最后，我们考虑了卡哈尔体与一系列人类疾病（包括癌症和遗传性神经退行性疾病）中明显的核结构改变之间出现的有趣联系。我们推测了卡哈尔体功能与分子疾病之间的关系。
