Department of Biomedical Systems and Technologies, Nalecz Institute of Biocybernetics and Biomedical Engineering, Polish Academy of Sciences, 4 Trojdena Street, Warsaw, Poland.
Med Biol Eng Comput. 2017 Nov;55(11):1937-1948. doi: 10.1007/s11517-017-1635-9. Epub 2017 Mar 25.
A new hybrid (numerical-physical) simulator of the respiratory system, designed to simulate spontaneous and artificial/assisted ventilation of preterm and full-term infants underwent preliminary evaluation. A numerical, seven-compartmental model of the respiratory system mechanics allows the operator to simulate global and peripheral obstruction and restriction of the lungs. The physical part of the simulator is a piston-based construction of impedance transformer. LabVIEW real-time software coordinates the work of both parts of the simulator and its interaction with a ventilator. Using clinical data, five groups of "artificial infants" were examined: healthy full-term infants, very low-birth-weight preterm infants successfully (VLBW) and unsuccessfully extubated (VLBWun) and extremely low-birth-weight preterm infants without (ELBW) and with bronchopulmonary dysplasia (ELBW_BPD). Pressure-controlled ventilation was simulated to measure peak inspiratory pressure, mean airway pressure, total (patient + endotracheal tube) airway resistance (R), total dynamic compliance of the respiratory system (C), and total work of breathing by the ventilator (WOB). The differences between simulation and clinical parameters were not significant. High correlation coefficients between both types of data were obtained for R, C, and WOB (γ = 0.99, P < 0.0005; γ = 0.85, P < 0.005; γ = 0.96, P < 0.05, respectively). Thus, the simulator accurately reproduces infant respiratory system mechanics.
一种新的呼吸系统混合（数值-物理）模拟器，旨在模拟早产儿和足月儿的自主和人工/辅助通气，已进行初步评估。呼吸系统力学的数值七腔室模型允许操作员模拟肺部的整体和外周阻塞和限制。模拟器的物理部分是基于活塞的阻抗变压器结构。LabVIEW 实时软件协调模拟器两部分及其与呼吸机交互的工作。使用临床数据，检查了五组“人工婴儿”：健康的足月儿、成功（VLBW）和不成功（VLBWun）拔管的极低出生体重早产儿以及无（ELBW）和有支气管肺发育不良（ELBW_BPD）的极低出生体重早产儿。模拟压力控制通气以测量吸气峰压、平均气道压、总（患者+气管内管）气道阻力（R）、呼吸系统总动态顺应性（C）和呼吸机总呼吸功（WOB）。模拟和临床参数之间的差异不显著。在 R、C 和 WOB 方面，两种类型的数据之间均获得了高度相关系数（γ=0.99，P<0.0005；γ=0.85，P<0.005；γ=0.96，P<0.05）。因此，模拟器准确地再现了婴儿呼吸系统力学。
