Department of Neonatal Paediatrics, University Hospital of North Tees, Stockton-on-Tees, UK.
Semin Fetal Neonatal Med. 2009 Dec;14(6):367-73. doi: 10.1016/j.siny.2009.08.011. Epub 2009 Sep 17.
Improvements in antenatal and neonatal care have resulted in increased survival of very preterm infants. However, the incidence of bronchopulmonary dysplasia (BPD) has not changed, probably as a consequence of a demographic shift. The underlying pathophysiology of BPD appears to differ for the current population of preterm infants compared to that described by Northway et al., and management strategies should be targeted to limit ventilator-induced lung injury. Non-invasive respiratory support techniques are currently under evaluation, but results of the trials have thus far failed to show a reduction in BPD. This review will focus upon various ventilation modalities for preventing and managing bronchopulmonary dysplasia.
产前和新生儿护理的改进导致非常早产儿的存活率提高。然而，支气管肺发育不良 (BPD) 的发病率并未改变，可能是由于人口结构的转变。与 Northway 等人描述的早产儿相比，当前早产儿人群中 BPD 的潜在病理生理学似乎有所不同，管理策略应针对限制呼吸机引起的肺损伤。目前正在评估非侵入性呼吸支持技术，但迄今为止，试验结果并未显示 BPD 减少。这篇综述将重点介绍预防和治疗支气管肺发育不良的各种通气方式。
