Kellermayer Richard
Section of Pediatric Gastroenterology, Department of Pediatrics, Baylor College of Medicine, Texas Children's Hospital, USDA/ARS Children's Nutrition Research Center, Houston, TX 77030, USA.
Epigenomics. 2017 Apr;9(4):527-538. doi: 10.2217/epi-2016-0155. Epub 2017 Mar 27.
The human epigenome may link environmental exposures and commensal microbiota changes to host pathology in respect to the developmental origins of inflammatory bowel diseases (ulcerative colitis [UC] and Crohn's disease [more appropriately Crohn disease, CD]). Genetic predisposition - prenatal, perinatal and pediatric environmental influences - microbiome aberration (dysbiosis) and immune dysregulation appear to be important elements in disease development, progression and maintenance. The prevalence of combined genetic and epigenetic susceptibility toward UC and CD is calculated herein to be as high as 2%, and approximately 1% for UC and CD in highly developed countries, respectively. This review emphasizes the significant challenges for epigenetic research in inflammatory bowel diseases. Overcoming these challenges, however, could reveal unique opportunities for disease prevention, treatment and possible cure.
就炎症性肠病（溃疡性结肠炎[UC]和克罗恩病[更确切地说是克罗恩病，CD]）的发育起源而言，人类表观基因组可能将环境暴露和共生微生物群变化与宿主病理联系起来。遗传易感性——产前、围产期和儿童期的环境影响——微生物群异常（生态失调）和免疫失调似乎是疾病发生、发展和维持的重要因素。本文计算得出，对UC和CD的遗传和表观遗传易感性合并患病率高达2%，在高度发达国家，UC和CD的患病率分别约为1%。本综述强调了炎症性肠病表观遗传学研究面临的重大挑战。然而，克服这些挑战可能会为疾病预防、治疗及可能的治愈带来独特机遇。
