宿主与微生物组多组学整合：应用与方法
Host and microbiome multi-omics integration: applications and methodologies.
作者信息
Wang Qing, Wang Kaicen, Wu Wenrui, Giannoulatou Eleni, Ho Joshua W K, Li Lanjuan
机构信息
State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, School of Medicine, Zhejiang University, No.79 Qingchun Road, Hangzhou, 310003, Zhejiang, China.
Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Hangzhou, China.
出版信息
Biophys Rev. 2019 Feb;11(1):55-65. doi: 10.1007/s12551-018-0491-7. Epub 2019 Jan 9.
Abstract
The study of the microbial community-the microbiome-associated with a human host is a maturing research field. It is increasingly clear that the composition of the human's microbiome is associated with various diseases such as gastrointestinal diseases, liver diseases and metabolic diseases. Using high-throughput technologies such as next-generation sequencing and mass spectrometry-based metabolomics, we are able to comprehensively sequence the microbiome-the metagenome-and associate these data with the genomic, epigenomics, transcriptomic and metabolic profile of the host. Our review summarises the application of integrating host omics with microbiome as well as the analytical methods and related tools applied in these studies. In addition, potential future directions are discussed.
摘要
对与人类宿主相关的微生物群落——微生物组的研究是一个不断成熟的研究领域。越来越明显的是，人类微生物组的组成与各种疾病相关，如胃肠道疾病、肝脏疾病和代谢疾病。利用下一代测序和基于质谱的代谢组学等高通量技术，我们能够对微生物组——宏基因组进行全面测序，并将这些数据与宿主的基因组、表观基因组、转录组和代谢谱相关联。我们的综述总结了整合宿主组学与微生物组的应用以及这些研究中应用的分析方法和相关工具。此外，还讨论了潜在的未来方向。
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